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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 2
1995 1
1997 2
1999 4
2000 4
2001 6
2002 11
2003 5
2004 8
2005 10
2006 3
2007 1
2008 7
2009 6
2010 7
2011 5
2012 3
2013 2
2014 3
2015 4
2016 3
2017 3
2018 3
2019 2
2020 2
2021 3
2022 3
2023 4
2024 2

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115 results

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Page 1
Conventional and genetic associations of adiposity with 1463 proteins in relatively lean Chinese adults.
Yao P, Iona A, Kartsonaki C, Said S, Wright N, Lin K, Pozarickij A, Millwood I, Fry H, Mazidi M, Chen Y, Du H, Bennett D, Avery D, Schmidt D, Pei P, Lv J, Yu C, Hill M, Chen J, Peto R, Walters R, Collins R, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group. Yao P, et al. Eur J Epidemiol. 2023 Oct;38(10):1089-1103. doi: 10.1007/s10654-023-01038-9. Epub 2023 Sep 7. Eur J Epidemiol. 2023. PMID: 37676424 Free PMC article.
Adiposity is associated with multiple diseases and traits, but little is known about the causal relevance and mechanisms underlying these associations. ...The findings among relatively lean Chinese adults identified novel pathways by which adiposity may increase disease ri …
Adiposity is associated with multiple diseases and traits, but little is known about the causal relevance and mechanisms underlying t …
Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model.
Zhou Z, Liu C, Xu S, Wang J, Guo F, Duan S, Deng Q, Sun J, Yu F, Zhou Y, Wang M, Wang Y, Zhou L, Jiang H, Yu L. Zhou Z, et al. Basic Res Cardiol. 2022 Jul 11;117(1):34. doi: 10.1007/s00395-022-00939-2. Basic Res Cardiol. 2022. PMID: 35819552
Chronic MI led to a decrease in the effective refractory period and action potential duration at 90% and deterioration in echocardiography performance, all of which was blunted by APN overexpression. Moreover, APN gene transfer resulted in favorable heart rate variability …
Chronic MI led to a decrease in the effective refractory period and action potential duration at 90% and deterioration in echocardiography p …
Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization.
Wu J, Fan Q, He Q, Zhong Q, Zhu X, Cai H, He X, Xu Y, Huang Y, Di X. Wu J, et al. Medicine (Baltimore). 2023 Dec 8;102(49):e36284. doi: 10.1097/MD.0000000000036284. Medicine (Baltimore). 2023. PMID: 38065874 Free PMC article.
LPA and APOA5 are involved in lipid metabolism and interact with target proteins of current MI medications. We also found 4 other proteins, IL1RN, FN1, NT5C, and SEMA3C, that may have potential as drug targets but require further confirmation. Our study demonstrates the ut …
LPA and APOA5 are involved in lipid metabolism and interact with target proteins of current MI medications. We also found 4 other proteins, …
Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Maori and Pacific ancestry.
Azevedo PM, Merriman TR, Topless RK, Wilson NJ, Crengle S, Lennon DR. Azevedo PM, et al. Cytokine. 2016 Sep;85:201-6. doi: 10.1016/j.cyto.2016.06.029. Epub 2016 Jul 9. Cytokine. 2016. PMID: 27400406
Confirmation of these previous associations could help guide clinical approaches. We aimed to test IL-6, IL-1RA (IL1RN), and CTLA4 functional SNPs in 204 rheumatic heart disease (RHD) patients and 116 controls of Maori and Pacific ancestry. ...The IL-6 promoter rs18 …
Confirmation of these previous associations could help guide clinical approaches. We aimed to test IL-6, IL-1RA (IL1RN), and CTLA4 fu …
Genetic Polymorphisms in Sepsis and Cardiovascular Disease: Do Similar Risk Genes Suggest Similar Drug Targets?
Nakada TA, Takahashi W, Nakada E, Shimada T, Russell JA, Walley KR. Nakada TA, et al. Chest. 2019 Jun;155(6):1260-1271. doi: 10.1016/j.chest.2019.01.003. Epub 2019 Jan 17. Chest. 2019. PMID: 30660782 Review.
Genetic variants are associated with altered clinical outcome of patients with sepsis and cardiovascular diseases. Common gene signaling pathways may be involved in the pathophysiology of these diseases. A better understanding of genetic commonality among these d …
Genetic variants are associated with altered clinical outcome of patients with sepsis and cardiovascular diseases. Common gene signal …
Potential Genes Associated with COVID-19 and Comorbidity.
Feng S, Song F, Guo W, Tan J, Zhang X, Qiao F, Guo J, Zhang L, Jia X. Feng S, et al. Int J Med Sci. 2022 Jan 24;19(2):402-415. doi: 10.7150/ijms.67815. eCollection 2022. Int J Med Sci. 2022. PMID: 35165525 Free PMC article.

Results showed that the associated overlapping genes were TLR4, NLRP3, MBL2, IL6, IL1RN, IL1B, CX3CR1, CCR5, AGT, ACE, and F2. GO and KEGG analyses yielded 302 GO terms (q < 0.05) and 29 signaling pathways (q < 0.05), respectively, mainly including coronavirus diseas

…
Results showed that the associated overlapping genes were TLR4, NLRP3, MBL2, IL6, IL1RN, IL1B, CX3CR1, CCR5, AGT, ACE, and F2. GO and …
Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease.
Baidildinova G, Pallares Robles A, Ten Cate V, Kremers BMM, Heitmeier S, Ten Cate H, Mees BME, Spronk HMH, Wild PS, Ten Cate-Hoek AJ, Jurk K. Baidildinova G, et al. Thromb Res. 2023 Oct;230:105-118. doi: 10.1016/j.thromres.2023.08.017. Epub 2023 Sep 2. Thromb Res. 2023. PMID: 37708596 Free article.
Using the Boruta random forest algorithm, the importance of 3 plasma proteins for HTPR in the aspirin, six in clopidogrel and 10 in the pooled group (clopidogrel or aspirin) was confirmed. Network analysis demonstrated clusters with CD84, SLAMF7, IL1RN and THBD for clopido …
Using the Boruta random forest algorithm, the importance of 3 plasma proteins for HTPR in the aspirin, six in clopidogrel and 10 in the pool …
Associations between interleukin-1 gene polymorphisms and coronary heart disease risk: a meta-analysis.
Zhou L, Cai J, Liu G, Wei Y, Tang H. Zhou L, et al. PLoS One. 2012;7(9):e45641. doi: 10.1371/journal.pone.0045641. Epub 2012 Sep 19. PLoS One. 2012. PMID: 23029154 Free PMC article.
OBJECTIVE: A great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1gene cluster and coronary heart disease (CHD) have been published. However, results have been inconsistent. ...
OBJECTIVE: A great number of studies regarding the associations between IL-1B-511, IL-1B+3954 and IL-1RN VNTR polymorphisms within the IL-1g …
What are the risks of biologic therapy in rheumatoid arthritis? An update on safety.
Weisman MH. Weisman MH. J Rheumatol Suppl. 2002 Sep;65:33-8. J Rheumatol Suppl. 2002. PMID: 12236621 Review.
Recently, a review of preliminary data from an ongoing phase II study suggests that infliximab may worsen congestive heart failure. On the basis of clinical trials, there appears to be a higher incidence of serious infections seen in anakinra patients compared with control …
Recently, a review of preliminary data from an ongoing phase II study suggests that infliximab may worsen congestive heart failure. O …
Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease.
Chen Y, Yang M, Zhang M, Wang H, Zheng Y, Sun R, Li X. Chen Y, et al. Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):866-882. doi: 10.1161/ATVBAHA.123.320188. Epub 2024 Feb 15. Arterioscler Thromb Vasc Biol. 2024. PMID: 38357816 Free article.
Our data indicated the presence of inflammatory cytokine storm in patients with KD with CALs, caused by systemic upregulation of TNFSF13B (tumor necrosis factor superfamily member 13b), CXCL16 (C-X-C motif chemokine ligand 16), TNFSF10 (tumor necrosis factor superfamily member 10 …
Our data indicated the presence of inflammatory cytokine storm in patients with KD with CALs, caused by systemic upregulation of TNFSF13B (t …
115 results